Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence

Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence.

It is known from clinical studies that some patients attempt to cope with the symptoms of post-traumatic stress disorder (PTSD) by using recreational drugs.

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Cannabinoids prevent the effects of a footshock followed by situational reminders on emotional processing

Cannabinoids prevent the effects of a footshock followed by situational reminders on emotional processing.

Posttraumatic stress disorder (PTSD) can develop following exposure to a traumatic event. Hence, what we do in the first few hours after trauma exposure may alter the trajectory of PTSD.

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THE ENDOCANNABINOID SYSTEM PROVIDES AN AVENUE FOR EVIDENCE-BASED TREATMENT DEVELOPMENT FOR PTSD

THE ENDOCANNABINOID SYSTEM PROVIDES AN AVENUE FOR EVIDENCE-BASED TREATMENT DEVELOPMENT FOR PTSD

Impaired extinction of aversive memories is associated with defective CB1 receptor signaling.

(Neumeister, A. (2013), THE ENDOCANNABINOID SYSTEM PROVIDES AN AVENUE FOR EVIDENCE-BASED TREATMENT DEVELOPMENT FOR PTSD. Depress. Anxiety, 30: 93–96. doi: 10.1002/da.22031)

http://onlinelibrary.wiley.com/doi/10.1002/da.22031/abstract

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Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder

Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder.

Many patients with post-traumatic stress disorder (PTSD) achieve but partial remission with current treatments. Patients with unremitted PTSD show high rates of substance abuse.

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