The influence of cannabinoids on generic traits of neurodegeneration

The influence of cannabinoids on generic traits of neurodegeneration
“In an increasingly ageing population, the incidence of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are rising. While the aetiologies of these disorders are different, a number of common mechanisms that underlie their neurodegenerative components have been elucidated; namely neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced trophic support.

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The Endocannabinoid System: A Putative Role in Neurodegenerative Diseases

The Endocannabinoid System: A Putative Role in Neurodegenerative Diseases

“Scientific evidence shows that an hypofunction or a dysregulation of the endocannabinoid system may be responsible for some of the symptoms of diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s, Parkinson’s and Alzheimer’s diseases.The aim of this review is to highlight the role of endocannabinoid system in neurodegenerative diseases.

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Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial

Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial.

“Parkinson’s disease (PD) has a progressive course and is characterized by the degeneration of dopaminergic neurons.… the endocannabinoid system has emerged as a promising target.…Our findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities…”

http://www.ncbi.nlm.nih.gov/pubmed/25237116  (PubMed)

 

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Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders

Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders

The following were studied in patients with MS: (1) Spasticity: oral cannabis extract (OCE) is effective, and nabiximols and tetrahydrocannabinol (THC) are probably effective, for reducing patient-centered measures; it is possible both OCE and THC are effective for reducing both patient-centered and objective measures at 1 year. (2) Central pain or painful spasms (including spasticity-related pain, excluding neuropathic pain): OCE is effective; THC and nabiximols are probably effective.

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