Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

We conclude that endocannabinoids tonically suppress cardiac contractility in hypertension and that enhancing the CB1-mediated cardiodepressor and vasodilator effects of endogenous anandamide by blocking its hydrolysis can normalize blood pressure. Targeting the endocannabinoid system offers novel therapeutic strategies in the treatment of hypertension.

(​PMID: 15451779 [PubMed - indexed for MEDLINE] PMCID: PMC2756479 )​

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756479/

 

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