Epilepsy Studies

EPILEPSY AND SEIZURES
CBD for children with Dravet’s and intractable seizures
http://youtu.be/BH5yzEu3JGQ (Video)

Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy 
http://www.ncbi.nlm.nih.gov/pubmed/24237632 (PubMed)

Medicinal marijuana stops seizures, brings hope to a little girl 
http://www.mapinc.org/drugnews/v13/n257/a05.html?1126 (Gazette, Colorado Springs)

Cannabinoids for epilepsy 
http://www.ncbi.nlm.nih.gov/pubmed/22696383 (PubMed)

Cannabis, cannabidiol, and epilepsy – From receptors to clinical response 
http://www.ncbi.nlm.nih.gov/pubmed/25282526 (PubMed)

The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability 
http://pubs.acs.org/doi/abs/10.1021/cn5000524?journalCode=acncdm (ACS Publications)

Chronic administration of cannabidiol to healthy volunteers and epileptic patients 
http://www.ncbi.nlm.nih.gov/pubmed/7413719 (PubMed)

Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

Anticonvulsant activity of four oxygenated cannabidiol derivatives.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9-tetrahydrocannabinol.

http://www.ncbi.nlm.nih.gov/pubmed/12...  (PubMed)

Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs.

http://www.ncbi.nlm.nih.gov/pubmed/12...  (PubMed)

Anticonvulsant action of cannabis in the rat: role of brain monoamines.

http://www.ncbi.nlm.nih.gov/pubmed/10...  (PubMed)

Antiepileptic potential of cannabidiol analogs.

http://www.ncbi.nlm.nih.gov/pubmed/72...  (PubMed)
 

The cannabinoids as potential antiepileptics.

http://www.ncbi.nlm.nih.gov/pubmed/69...  (PubMed)

Hypnotic and antiepileptic effects of cannabidiol.

http://www.ncbi.nlm.nih.gov/pubmed/70...  (PubMed)

Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.

http://www.ncbi.nlm.nih.gov/pubmed/61...  (PubMed)

Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

On the application of cannabis in paediatrics and epileptology.

http://www.ncbi.nlm.nih.gov/pubmed/15...  (PubMed)

Endocannabinoids and Their Implications for Epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

Cannabinoids: Defending the Epileptic Brain

http://www.ncbi.nlm.nih.gov/pmc/artic...

Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid.

http://www.ncbi.nlm.nih.gov/pubmed/15...  (PubMed)

Cannabinoids as potential anti-epileptic drugs.

http://www.ncbi.nlm.nih.gov/pubmed/16...  (PubMed)

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

http://www.ncbi.nlm.nih.gov/pmc/artic...

Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.

http://www.ncbi.nlm.nih.gov/pubmed/16...  (PubMed)

Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus

http://www.ncbi.nlm.nih.gov/pmc/artic...

Endocannabinoids block status epilepticus in cultured hippocampal neurons

http://www.ncbi.nlm.nih.gov/pmc/artic... 

Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.

http://www.ncbi.nlm.nih.gov/pubmed/17...  (PubMed)

The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum

http://www.ncbi.nlm.nih.gov/pmc/artic...

The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice.

http://www.ncbi.nlm.nih.gov/pubmed/18...  (PubMed)

Prolonged exposure to WIN55,212-2 causes down-regulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

http://www.ncbi.nlm.nih.gov/pubmed/19...  (PubMed)

Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.

http://www.ncbi.nlm.nih.gov/pubmed/19...  (PubMed)

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

http://www.ncbi.nlm.nih.gov/pmc/artic...

Cannabinoid-Mediated Inhibition of Recurrent Excitatory Circuitry in the Dentate Gyrus in a Mouse Model of Temporal Lobe Epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

AAV Vector-Mediated Overexpression of CB1 Cannabinoid Receptor in Pyramidal Neurons of the Hippocampus Protects against Seizure-Induced Excitoxicity

http://www.ncbi.nlm.nih.gov/pmc/artic...

Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.

http://www.ncbi.nlm.nih.gov/pubmed/20...  (PubMed)

Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.

http://www.ncbi.nlm.nih.gov/pubmed/20...  (PubMed)

Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/21...  (PubMed)

L-type calcium channel mediates anticonvulsant effect of cannabinoids in acute and chronic murine models of seizure.

http://www.ncbi.nlm.nih.gov/pubmed/21...  (PubMed)

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis.

http://www.ncbi.nlm.nih.gov/pubmed/21...  (PubMed)

Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.

http://www.ncbi.nlm.nih.gov/pubmed/23...  (PubMed)

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/23...  (PubMed)

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