Cannabinoid Receptor CB2 Modulates Axon Guidance

Cannabinoid Receptor CB2 Modulates Axon Guidance.

“Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms.

Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino-thalamic pathway and exerts a modulatory action on axon guidance….

Overall, this study demonstrates that the contribution of endocannabinoids to brain development is not solely mediated by CB1R, but also involves CB2R.”

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