The endocannabinoid system modulates stress, emotionality, and inflammation

The endocannabinoid system modulates stress, emotionality, and inflammation.

The physiological and behavioral effects of stress are well characterized. Endocannabinoids are produced on demand and function to attenuate many of the physiological effects of the stress response.

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Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown.

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Endocannabinoid signaling in Alzheimer’s disease: current knowledge and future directions

Endocannabinoid signaling in Alzheimer’s disease: current knowledge and future directions.

“The importance of the endocannabinoid system (ECS) in the modulation functions of the central nervous system has been extensively investigated during the last few years.

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Prevention of Alzheimer’s Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation

“Prevention of Alzheimer’s Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation” 

Alzheimer's disease (AD) is characterized by enhanced β-amyloid peptide (βA) deposition along with glial activation in senile plaques, selective neuronal loss, and cognitive deficits.

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The endocannabinoid system: a putative role in neurodegenerative diseases

The endocannabinoid system: a putative role in neurodegenerative diseases.

“Scientific evidence shows that an hypofunction or a dysregulation of the endocannabinoid system may be responsible for some of the symptoms of diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s, Parkinson’s and Alzheimer’s diseases.

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The Potential Therapeutic Effects of THC on Alzheimer’s Disease

The Potential Therapeutic Effects of THC on Alzheimer’s Disease. 

“The purpose of this study was to investigate the potential therapeutic qualities of Δ9-tetrahydrocannabinol (THC) with respect to slowing or halting the hallmark characteristics of Alzheimer’s disease…

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The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease

The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease.

“Alzheimer’s disease (AD) is the most common form of progressive neurodegenerative disease characterized by cognitive impairment and mental disorders… AD is multifaceted in nature and is linked to different multiple mechanisms in the brain…

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Leukemia Studies

Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis. (1977)
http://www.ncbi.nlm.nih.gov/sites/ent...

Cannabinoids induce incomplete maturation of cultured human leukemia cells (1987)
http://www.ncbi.nlm.nih.gov/pmc/artic...

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells. (2003)
http://www.ncbi.nlm.nih.gov/sites/ent...

Is there a temperature-dependent uptake of anandamide into cells? (2006)
http://www.ncbi.nlm.nih.gov/pmc/artic...

The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. (2006) 
http://www.ncbi.nlm.nih.gov/pubmed/16...

Enhancing the in vitro cytotoxic activity of Δ9-tetrahydrocannabinol in leukemic cells through a combinatorial approach (2008)
http://www.ncbi.nlm.nih.gov/pubmed/18...

Substance use and survival after treatment for chronic myelogenous leukemia (CML) or myelodysplastic syndrome (MDS). (2010)
http://www.ncbi.nlm.nih.gov/pmc/artic...

{Delta}9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria (2006) 
http://mcr.aacrjournals.org/content/4...

Cannabidiol-Induced Apoptosis in Human Leukemia Cells : A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression (2006)
http://molpharm.aspetjournals.org/cgi...


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Lukemia Studies

Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis. (1977)

http://www.ncbi.nlm.nih.gov/sites/ent...

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Epilepsy Studies

EPILEPSY AND SEIZURES
CBD for children with Dravet’s and intractable seizures
http://youtu.be/BH5yzEu3JGQ (Video)

Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy 
http://www.ncbi.nlm.nih.gov/pubmed/24237632 (PubMed)

Medicinal marijuana stops seizures, brings hope to a little girl 
http://www.mapinc.org/drugnews/v13/n257/a05.html?1126 (Gazette, Colorado Springs)

Cannabinoids for epilepsy 
http://www.ncbi.nlm.nih.gov/pubmed/22696383 (PubMed)

Cannabis, cannabidiol, and epilepsy – From receptors to clinical response 
http://www.ncbi.nlm.nih.gov/pubmed/25282526 (PubMed)

The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability 
http://pubs.acs.org/doi/abs/10.1021/cn5000524?journalCode=acncdm (ACS Publications)

Chronic administration of cannabidiol to healthy volunteers and epileptic patients 
http://www.ncbi.nlm.nih.gov/pubmed/7413719 (PubMed)

Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

Anticonvulsant activity of four oxygenated cannabidiol derivatives.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9-tetrahydrocannabinol.

http://www.ncbi.nlm.nih.gov/pubmed/12...  (PubMed)

Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs.

http://www.ncbi.nlm.nih.gov/pubmed/12...  (PubMed)

Anticonvulsant action of cannabis in the rat: role of brain monoamines.

http://www.ncbi.nlm.nih.gov/pubmed/10...  (PubMed)

Antiepileptic potential of cannabidiol analogs.

http://www.ncbi.nlm.nih.gov/pubmed/72...  (PubMed)
 

The cannabinoids as potential antiepileptics.

http://www.ncbi.nlm.nih.gov/pubmed/69...  (PubMed)

Hypnotic and antiepileptic effects of cannabidiol.

http://www.ncbi.nlm.nih.gov/pubmed/70...  (PubMed)

Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.

http://www.ncbi.nlm.nih.gov/pubmed/61...  (PubMed)

Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/11...  (PubMed)

On the application of cannabis in paediatrics and epileptology.

http://www.ncbi.nlm.nih.gov/pubmed/15...  (PubMed)

Endocannabinoids and Their Implications for Epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

Cannabinoids: Defending the Epileptic Brain

http://www.ncbi.nlm.nih.gov/pmc/artic...

Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid.

http://www.ncbi.nlm.nih.gov/pubmed/15...  (PubMed)

Cannabinoids as potential anti-epileptic drugs.

http://www.ncbi.nlm.nih.gov/pubmed/16...  (PubMed)

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

http://www.ncbi.nlm.nih.gov/pmc/artic...

Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.

http://www.ncbi.nlm.nih.gov/pubmed/16...  (PubMed)

Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus

http://www.ncbi.nlm.nih.gov/pmc/artic...

Endocannabinoids block status epilepticus in cultured hippocampal neurons

http://www.ncbi.nlm.nih.gov/pmc/artic... 

Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.

http://www.ncbi.nlm.nih.gov/pubmed/17...  (PubMed)

The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum

http://www.ncbi.nlm.nih.gov/pmc/artic...

The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice.

http://www.ncbi.nlm.nih.gov/pubmed/18...  (PubMed)

Prolonged exposure to WIN55,212-2 causes down-regulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

http://www.ncbi.nlm.nih.gov/pubmed/19...  (PubMed)

Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.

http://www.ncbi.nlm.nih.gov/pubmed/19...  (PubMed)

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

http://www.ncbi.nlm.nih.gov/pmc/artic...

Cannabinoid-Mediated Inhibition of Recurrent Excitatory Circuitry in the Dentate Gyrus in a Mouse Model of Temporal Lobe Epilepsy

http://www.ncbi.nlm.nih.gov/pmc/artic...

AAV Vector-Mediated Overexpression of CB1 Cannabinoid Receptor in Pyramidal Neurons of the Hippocampus Protects against Seizure-Induced Excitoxicity

http://www.ncbi.nlm.nih.gov/pmc/artic...

Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.

http://www.ncbi.nlm.nih.gov/pubmed/20...  (PubMed)

Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.

http://www.ncbi.nlm.nih.gov/pubmed/20...  (PubMed)

Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/21...  (PubMed)

L-type calcium channel mediates anticonvulsant effect of cannabinoids in acute and chronic murine models of seizure.

http://www.ncbi.nlm.nih.gov/pubmed/21...  (PubMed)

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis.

http://www.ncbi.nlm.nih.gov/pubmed/21...  (PubMed)

Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201.

http://www.ncbi.nlm.nih.gov/pubmed/22...  (PubMed)

Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.

http://www.ncbi.nlm.nih.gov/pubmed/23...  (PubMed)

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/23...  (PubMed)

This Research and Resources page is sponsored by the Ohio Rights Group Education Fund.
Please support our charitable and educational work by making a generous tax deductible donation.

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