Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury

Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury.

Abstract

Cannabidiol (CBD), a non-psychoactive constituent of cannabis, has been reported to induce neuroprotective effects in several experimental models of brain injury. We aimed at investigating whether this drug could also improve locomotor recovery of rats submitted to spinal cord cryoinjury.

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Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal

Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal

Paclitaxel-induced mechanical and cold allodynia developed to an equivalent degree in CB1KO, CB2KO, and WT mice. Both AM1710 and Δ9-THC suppressed established paclitaxel-induced allodynia in WT mice. In contrast to Δ9-THC, chronic administration of AM1710 did not engage CB1 activity or produce antinociceptive tolerance, CB1-mediated cannabinoid withdrawal, hypothermia, or motor dysfunction.

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Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain

Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain

A number of studies have shown that activation of the cannabinoid (CB) receptor leads to a robust antinociception in a variety of preclinical pain models [3].

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Back Pain & Spinal Cord Injuries

Cannabis Research - Back Pain/Spinal Cord Injuries
Back Pain due to degenerated disk - Therapeutic role of Cannabis (2005)
http://www.bjjprocs.boneandjoint.org...

Investigational pharmacology for low back pain (2010)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004649/?tool=pmcentrez

Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (2012) 
http://www.ncbi.nlm.nih.gov/pubmed/22354705

 

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