Cannabinoid system of the lateral septum in the modulation of anxiety-like behaviors in rats

Cannabinoid system of the lateral septum in the modulation of anxiety-like behaviors in rats.

A large body of evidence suggests that the cannabinoid CB1 receptor plays a key role in the regulation of emotional behaviors.

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The endocannabinoid system modulates stress, emotionality, and inflammation

The endocannabinoid system modulates stress, emotionality, and inflammation.

The physiological and behavioral effects of stress are well characterized. Endocannabinoids are produced on demand and function to attenuate many of the physiological effects of the stress response.

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Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown.

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